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Fibroids

Fibroid Symptom: Menorrhagia

What do heavy menstrual cycles, fatigue, dizziness, pelvic pressure and bloating, enlargement of the abdomen, constipation, increased urinary frequency, heavy bleeding (menorrhagia), pain during sex, and even infertility all have in common?

If you guessed “symptoms caused by uterine fibroids.”

You’re right!

Although fibroids are non-cancerous, due to the many painful, uncomfortable, and life-limiting side effects, many women choose to have them removed.

One of the most common and frustrating symptoms of uterine fibroids is heavy bleeding, also known as menorrhagia.

It is estimated that as many as 35 percent of women in their reproductive years experience menorrhagia, and fibroids can be a leading cause of this.

In fact, fibroids have been found in more than 10% of women with menorrhagia overall and in 40% of women with severe menorrhagia.

According to the National Library of Medicine (NLM), an estimated 26 million women between 15 and 50 have uterine fibroids. Of those, nearly 15 million women experience associated symptoms or linked health-related problems, such as heavy menstrual bleeding.

So what is considered to be heavy bleeding, and how do fibroids contribute to this?

Most gynecologists and physicians agree that heavy bleeding can be defined as:

–  Bleeding that lasts for longer than eight days.

–  Bleeding that requires frequent sanitary pad or tampon changes, approximately every hour or more.

Why do fibroids cause heavy bleeding?

While there is no one reason that heavy bleeding occurs with fibroids, there are several factors that contribute to this symptom, including:

–  Added pressure on the uterus from the fibroids

–  Irregular contractions of the uterus

–  Blood vessel growth stimulation caused by fibroids increases the amount and frequency of bleeding and spotting between periods

–  Elevated hormone levels

Fortunately, there are several treatment options for women with fibroids, which can help reduce or resolve completely, the symptom of heavy bleeding.

The most common treatment methods for fibroid-related menorrhagia include medication and major surgery such as a hysterectomy or a myomectomy. As well as, a procedure that has been rapidly gaining in popularity for its effectiveness and shorter recovery time, which is called Uterine Fibroid Embolization.

Since 1995, Uterine Fibroid Embolization, which is a non-invasive procedure performed either solely or primarily through the uterine artery, has been helping women who suffer health issues related to uterine fibroids. Furthermore, as UFE continues to grow in popularity as a treatment method for uterine fibroids, a plethora of research continues to document its promising results.

The goal of this procedure is to relieve symptoms by blocking the artery that is supplying blood to the fibroids, which causes them to shrink and die.

So how effective is this procedure in relieving the symptoms of fibroid-related heavy bleeding?

It is very effective.

In fact, multiple studies show that fibroid embolization is at least 90% effective when it comes to reducing fibroid-related bleeding and pain.

Not only that, but time and time again, women are reporting that they are experiencing a significant change in their fibroid symptoms within days following the procedure.

This is incredible, especially considering that other treatment methods can take months to show signs of improvement.

One of the earliest studies of the effectiveness of UFE was published in The Journal of the American Association of Gynecologic Laparoscopists.

The study followed up with 305 women who were treated with the procedure, up to a year after treatment, and what they found was quite promising.

They found that the symptom of heavy bleeding was controlled in 86% of patients at 3 months and 92% at 12 months. And, they also found that the bulk of fibroid symptoms was controlled in 64% of patients at 3 months and 92% at 12 months.

Another study, which was published in the medical journal Radiology reported the results of following up with 80 consecutive patients treated with UFE for menorrhagia caused by fibroids.

Researchers followed up with this group of women for a minimum of 2 years and discovered that menorrhagia was controlled in over 90% of these women!

These are just a few of the studies regarding the impact that Uterine Fibroid Embolization can have on relieving the fibroid symptom of heavy bleeding. A simple google search will bring up study after study where the findings are similar to those stated above.

But wait…there’s more…much more.

In our next article, we will look at what the research says regarding the impact that Uterine Fibroid Embolization can have on some of the other common symptoms of uterine fibroids such as pelvic pressure and pain.

Categories
Fibroids

Tranexamic Acid for Fibroids

Heavy menstrual bleeding from fibroids is often accompanied by heavy cramping, both of which leave those inflicted, fatigued, and sometimes unable to work and fully participate in their lives.

In the earlier stages of fibroids, some physicians will try to control the common symptoms of heavy bleeding with oral contraceptives or GnRH agonists and will treat pain and discomfort with anti-inflammatory drugs. However, if this isn’t working, another option your doctor may try is the use of tranexamic acid.

For several decades the medical field has relied on tranexamic acid to help blood clot in order to reduce blood loss during surgery, or as a result of trauma, childbirth, and more. Belonging to a category of drugs called antifibrinolytics, tranexamic acid works by preventing the breakdown of a protein called fibrin, which is the main protein in a blood clot.

The history of using tranexamic acid in the treatment of heavy bleeding caused by menstruation, trauma, and childbirth, is a rather interesting one. It all started in Japan in the 1950s, at a time when postpartum hemorrhage was a leading cause of maternal death.

Utako and Shosuke Okamoto, a Japanese husband, and wife, both biochemists in Tokyo, had been working diligently to identify a drug that could reduce the risk of postpartum hemorrhaging and save more women. The couple knew that there was an enzyme in the blood that breaks down blood clots, and sought to discover a medicine that would inhibit this action. What they discovered was the bleeding reduction effect of tranexamic acid.

In 1962, Utako and Shosuke Okamoto, published their findings in The Keio Journal of Medicine. Though at first, practitioners were slow to start using tranexamic acid, eventually it caught on as a useful treatment to control bleeding during routine procedures such as tooth extractions.

Following a few years of further research regarding the effectiveness of tranexamic acid, the medical field finally began to utilize this form of treatment. As a result, tranexamic acid is now used to treat bleeding-related issues in everything from that of trauma patients, pregnant women, hemophiliacs, and women experiencing too much blood loss during menstruation due to fibroid-related heavy bleeding, as well as other uterine conditions.

Though tranexamic acid is effective in controlling blood loss during surgery or as a result of trauma, the only FDA-approved usage of tranexamic acid is for heavy menstrual bleeding ( caused by fibroids or other conditions) and hemophiliacs.

Tranexamic acid comes in a tablet form and is usually taken with or without food three times a day for up to 5 days during monthly menstruation, starting on the first day of a period. These tablets need to be taken at around the same time every day of a menstrual period.

Though it is effective at reducing menstrual bleeding, tranexamic acid isn’t without its problems.

For starters, it’s expensive.

Sold under the brand name Lysteda, tranexamic acid can cost around $170 for 30 tablets of 650 mg. Not only is it a little pricey, but it can also have the following side effects:

abdominal or stomach pain, discomfort, or tenderness
fever or chills
difficulty with moving
headache, severe and throbbing
joint or back pain
muscle aching or cramping
muscle pains or stiffness
stuffy or runny nose
fatigue

Tranexamic acid also has many drug interactions that are not safe, and it can not be taken with any of the following medications:

estrogens
birth control pills, patches, injections, rings or other devices that contain both estrogen and a progestin
certain medicines used to help your blood clot
tretinoin (taken by mouth)

The Bottom Line:

Tranexamic acid is a nonhormonal option that reduces menstrual blood loss in patients with heavy menstrual bleeding due to uterine fibroids. Though it is more expensive than oral contraceptives, anti-inflammatory drugs, and hormone therapies- it is an option when those treatments are not recommended or desired. That being said, tranexamic acid may reduce fibroid-related heavy bleeding, however, it does not affect or address the underlying cause- The fibroids themselves.

In order to truly eliminate fibroid symptoms, fibroids need to be treated directly. In our next article, we will begin to look at surgeries and non-invasive procedures that can shrink and/or eliminate uterine fibroids.